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Pharmaceutical Biotechnology

PHAR 5215 - Pharmaceutical Biotechnology

A survey of medicinal chemistry and pharmaceutics of pharmaceutical products derived from modern methods of molecular biology. This course will consider products in use or in clinical trials to emphasize the conceptual basis, design, and synthesis of biotech products in the context of current practical applications.

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PHAR 5216 - Dosage Forms I

Introduces the student to the principles of thermodynamics, ionic equilibrium, chemical kinetics and diffusion. Application of these principles to formulation, stability and dissolution of a drug product, and release from the dosage form for optimum therapeutic outcome. Required of entering graduate students in Pharmaceutics who do not have a Pharmacy background as well as those who do not pass the qualifying examination within the first year of the program.

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PHAR 5217 - Dosage Forms II

Covers the basic principles of the surface and colloid chemistry and rheology, as these relate to the performance of dispersed system dosage forms including colloids, suspensions, emulsions, suppositories, aerosols, ointments, and transdermals. Required of entering graduate students in Pharmaceutics who do not have a Pharmacy background, and those who do not pass the qualifying examination within the first year of the program.

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PHAR 5219 - Biopharmaceutics and Pharmacokinetics

Basic principles of biopharmaceutics, bioavailability, and pharmacokinetics, including their application to the rational design of both dosage forms and maximally effective dosing regimens. Intended for graduate students who may not have sufficient previous exposure to biopharmaceutics and pharmakokinetics.

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PHAR 5239 - Current Literature in Pharmaceutics

Designed to familiarize students with current pharmaceutics literature and to educate students in critical peer revirew in the pharmaceutics literature.

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PHAR 5293 - Seminar in Pharmaceutics

Reports and discussions.Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatistactory.)

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PHAR 5295 - Special Problems in Pharmaceutics

Individualized course for students desiring research experience in any of the areas of pharmacy other than the area chosen by the student for thesis research.

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PHAR 5297 - Special Topics in Pharmaceutics

Includes topics not presently covered in courses which are pertinent to current departmental research and areas of recent development in the literature.

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PHAR 5301 - Macromolecules in Drug Design

A cooperative presentation of the fundamentals of medicinal chemistry.

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PHAR 5302 - Chemical Biology and Drug Design

The overall goal of this course is to introduce students to the emerging field of chemical biology with a particular focus on the role it plays in understanding cellular signaling, drug design, and drug development.

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PHAR 5303 - Small Molecule Structure and Function

Small organic molecules continue to be the preeminent form of therapeutic agents. The small molecules that constitute clinically used agents are developed through a highly interdisciplinary process involving chemists, biologists and healthcare workers in a process commonly referred to as drug discovery. The purpose of this course is to provide the student with a broad view of drug properties, drug function and the drug discovery process.

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PHAR 5308 - Structure and Function of Biological Membranes

Overview of cell membrane structure and function based on a foundation of physical and biochemistry principles. Topics include lipid bilayers, vesicles and liposomes, cholesterol, membrane protein structure and function, transport, membrane fusion, receptors, drug/membrane interactions and membranes in cell regulation.

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PHAR 5393 - Seminar in Medicinal Chemistry

Reports and discussions.Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatistactory.)

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PHAR 5395 - Special Problems in Medicinal Chemistry

Individualized course for students desiring research experience in any of the areas of medicinal chemistry other than the area chosen by the student for thesis research.

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PHAR 5397 - Special Topics in Medicinal Chemistry

Current developments in Medicinal Chemistry. A course for students needing exposure to topics not covered in other department offerings.

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PHAR 5403 - Current Toxicology Literature

Designed to familiarize students with current toxicology literature and to educate students in critical peer review of this toxicology literature.Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatistactory.)

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PHAR 5454 - Principles of Safety Evaluation

Introduction to toxicologic risk assessment. Fundamentals of dose-response relationships and risk characterization, and their application in the establishment of permissible exposure limits for drugs and other chemicals in the environment or workplace.

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PHAR 5458 - Analytical Toxicology

Qualitative and quantitative determination of xenobiotics. Isolation techniques; principles of chromatography and spectrometry; theory, instrumentation and analysis of data.

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PHAR 5471 - Advanced Pharmacology I: Basic Principles

Molecular mechanisms of drug action including occupation and rate theories. Characterization of receptors in-situ and in-vitro.

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PHAR 5472 - Advanced Pharmacology II: Drug Disposition

Drug absorption, distribution, excretion, metabolism, interaction, allergy, resistance, tolerance, idiosyncrasy and toxicity.

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PHAR 5475 - Toxicology Scholars Colloquium

Reviews, discussions and seminars focused on the research of scientists who have made significant contributions to the science of toxicology.

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PHAR 5493 - Seminar in Pharmacology and Toxicology

Reports and discussions on journal and review articles and presentation of personal research results.Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatistactory.)

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PHAR 5494 - Seminar in Immunology

Reports and discussions.Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatistactory.)

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PHAR 5495 - Special Problems in Pharmacology I

The course is individualized for students desiring research experience in any of the areas of pharmacology.

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PHAR 5496 - Special Problems in Toxicology

Individualized course for students desiring research experience in any of the areas of toxicology.

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PHAR 5497 - Special Topics in Pharmacology

Includes topics not presently covered in courses, which are pertinent to current departmental research and areas of recent development in the literature.

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PHAR 5498 - Special Topics in Toxicology

Basic principles of toxicology as emphasized by recent developments in the biochemical toxicology literature.

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PHAR 5746 - Introduction to Managed Care Pharmacy

A study of managed care pharmacy within the United States health care system, with emphasis on managed care organization and control, pharmacy benefits design and management, outcomes measurement, pharmacoeconomics, health care provider and client education, benefits plan financing and marketing, and legal issues of managed care pharmacy.

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PHAR 5764 - Advanced Pharmacy Administration

A study of modern management techniques applicable in terminal drug distribution. Special emphasis is placed upon quantitative methods and the utilization of electronic data processing.

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PHAR 5793 - Seminar in Pharmacy Administration

Reports and discussions.Students taking this course will be assigned a final grade of S (satisfactory) or U (unsatistactory.)

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PHAR 5795 - Special Problems in Pharmacy Practice

Individualized course for students desiring research experience in pharmacy administration or hospital pharmacy administration.

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PHAR 5797 - Special Topics in Pharmacy Administration

Current developments in Pharmacy Administration. A course for students needing exposure to topics not covered in other Department of Pharmacy Practice offerings.

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PHAR 6234 - Advanced Biopharmaceutics

Overview of physico-chemical, biopharmaceutic, and physiologic factors controlling the delivery of drug and their sites of action.

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PHAR 6241 - Advanced Kinetics and Mechanisms of Drug Degradation

An advanced treatment of the physical organic chemistry critical to the characterization and understanding of stability in pharmaceutical products.

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PHAR 6242 - Freeze Drying of Pharmaceuticals

The science and technology of freeze drying, including fundamentals of heat and mass transfer gas systems, process design considerations, and formulation strategies with emphasis on stabilization of therapeutic proteins.

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PHAR 6285 - Complex Equilibria

A study of the physico-chemical and mathematical treatment in pharmaceutical systems. Topics center on thermodynamics, activity coefficients, acids and bases, solubility, complexation solubilization and protein binding.

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PHAR 6286 - Transport Processes

Emphasis is on the application of the laws of diffusion to dissolution, membrane transport and release of drugs from dosage forms.

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PHAR 6288 - Kinetics and Mechanisms of Drug Degradation and Stability

A study of the kinetics and mechanisms of drug degradation in the solid and liquid states and drug stabilization.

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PHAR 6289 - Pharmacokinetics

A discussion of absorption, distribution, and clearance mechanisms, and their impact on concentration-time profiles and drug response.

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PHAR 6290 - Colloid Chemistry and Interfacial Phenomena

Interfacial phenomena, colloid chemistry.

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PHAR 6452 - Toxicology of the Respiratory System

Anatomic and functional aspects of toxic injury to the respiratory tract with an emphasis on biochemical and physiologic mechanisms of toxic pulmonary injury. Lectures and student presentations.

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PHAR 6455 - Advanced Toxicology

A study of the harmful effects of toxic chemicals on biological systems. Emphasis is on mechanisms of toxicant action and on practical applications of modern techniques to assess toxicity and hazard.

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PHAR 6459 - Immunotoxicology

Demonstrates the detrimental effects on the immune system and/or inflammatory response, by a variety of physical and chemical xenobiotics. Emphasis is placed on the mechanisms of chemical and drug-induced immunosuppression, autoimmune response, and allergic response.

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PHAR 6465 - Pharmacology of the Circulatory System

A study of the cardiovascular system. Both physiological and pharmacological responses of the cardiovascular system are reviewed. Emphasis is placed upon the biochemical and physiological changes associated with atherosclerosis.

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PHAR 6473 - Function and Dysfunction of Brain Synapses

This course covers the functional and structural regulation events that influence synaptic activity, as well as corresponding ideas related to memory encoding. In addition, pathogenic processes are addressed which have a negative influence on brain circuits. These include age-related changes, stroke, and Alzheimer-type pathogenesis. Lastly, new and future therapeutic strategies are discussed in regard to the enhancement of memory mechanisms and repair systems. The format of the course is formal lectures and journal article discussions by students.

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PHAR 6475 - Mechanistic Toxicology I

Mechanistic toxicology describes the processes of how chemicals exert their toxic effects in biological systems. Therefore, understanding of the underlying mechanisms of toxicity, together with exposure estimates, provides key information that links the toxic hazard of a chemical with the actual human health risk. This first course explores some fundamental cellular and molecular mechanisms of toxicity and integrates them into a larger picture; reactive intermediates, oxidative and nitrative stress, and mitochondria-mediated toxicity will be covered. The basic concepts will be illustrated with specific examples (drugs and environmental chemicals).

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PHAR 6484 - Cutaneous Differentiation: Molecular Mechanisms and Cellular Processes

This course examines mammalian skin structure, keratinocyte, immune and pigment cells, mechanisms of mesenchymal-epithelial induction, replication- and cytoskeletal-based diseases, stem cell identification and plasticity, and transcriptional regulation of differentiation-dependent gene expression.

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